期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 34, 期 7, 页码 1107-1110出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2014.79
关键词
cerebral malaria; endothelial glycocalyx; glycosaminoglycans; Plasmodium berghei ANKA; Plasmodium chabaudi AS; transmission electron microscopy
资金
- Forskningsudvalget at Copenhagen University Hospital
- Fonden for Laegevidenskabens Fremme
- Augustinusfonden
We hypothesized that the glycocalyx, which is important for endothelial integrity, is lost in severe malaria. C57BL/6 mice were infected with Plasmodium berghei ANKA, resulting in cerebral malaria, or R chabaudi AS, resulting in uncomplicated malaria. We visualized the glycocalyx with transmission electron microscopy and measured circulating glycosaminoglycans by dot blot and ELISA. The glycocalyx was degraded in brain vasculature in cerebral and to a lesser degree uncomplicated malaria. It was affected on both intact and apoptotic endothelial cells. Circulating glycosaminoglycan levels suggested that glycocalyx disruption preceded cerebral manifestations. The contribution of this loss to pathogenesis should be studied further.
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