期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 32, 期 10, 页码 1869-1878出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2012.96
关键词
cerebrovascular disease; diffusion tensor imaging; MRI; vascular cognitive impairment; white matter disease
资金
- LIFE-Leipzig Research Center for Civilization Diseases at the University of Leipzig
- European Union
- European Regional Development Fund
- Free State of Saxony
- German Consortium for Frontotemporal Lobar Degeneration
- German Federal Ministry of Education and Research
- IFB-Integrated Research and Treatment Center Adiposity Diseases at the University of Leipzig
Cerebral microangiopathy (CMA) has been associated with executive dysfunction and fronto-parietal neural network disruption. Advances in magnetic resonance imaging allow more detailed analyses of gray (e.g., voxel-based morphometry-VBM) and white matter (e.g., diffusion tensor imaging-DTI) than traditional visual rating scales. The current study investigated patients with early CMA and healthy control subjects with all three approaches. Neuropsychological assessment focused on executive functions, the cognitive domain most discussed in CMA. The DTI and age-related white matter changes rating scales revealed convergent results showing widespread white matter changes in early CMA. Correlations were found in frontal and parietal areas exclusively with speeded, but not with speed-corrected executive measures. The VBM analyses showed reduced gray matter in frontal areas. All three approaches confirmed the hypothesized fronto-parietal network disruption in early CMA. Innovative methods (DTI) converged with results from conventional methods (visual rating) while allowing greater spatial and tissue accuracy. They are thus valid additions to the analysis of neural correlates of cognitive dysfunction. We found a clear distinction between speeded and nonspeeded executive measures in relationship to imaging parameters. Cognitive slowing is related to disease severity in early CMA and therefore important for early diagnostics. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 1869-1878; doi:10.1038/jcbfm.2012.96; published online 11 July 2012
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据