期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 33, 期 2, 页码 191-195出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2012.132
关键词
animal models; electrophysiology; glucose; migraine; spreading depression
资金
- National Institutes of Health [NS055104, NS061505]
Spreading depression of Leao is an intense spreading depolarization (SD) wave associated with massive transmembrane ionic, water, and neurotransmitter shifts. Spreading depolarization underlies migraine aura, and occurs in brain injury, making it a potential therapeutic target. While susceptibility to SD can be modulated pharmacologically, much less is known about modulation by systemic physiological factors, such as the glycemic state. In this study, we systematically examined modulation of SD susceptibility by blood glucose in anesthetized rats under full physiological monitoring. Hyperglycemia and hypoglycemia were induced by insulin or dextrose infusion (blood glucose similar to 40 and 400 mg/dL, respectively). Spreading depolarizations were evoked by direct cortical electrical stimulation to determine the intensity threshold, or by continuous topical KCI application to determine SD frequency. Hyperglycemia elevated the electrical SD threshold and reduced the frequency of KCI-induced SDs, without significantly affecting other SD properties. In contrast, hypoglycemia significantly prolonged individual and cumulative SD durations, but did not alter the electrical SD threshold, or SD frequency, amplitude or propagation speed. These data show that increased cerebral glucose availability makes the tissue resistant to SD. Journal of Cerebral Blood Flow & Metabolism (2013) 33, 191-195; doi:10.1038/jcbfm.2012.132; published online 12 September 2012
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