期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 31, 期 6, 页码 1339-1345出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2011.19
关键词
hydrogen clearance; optical coherence tomography; optical imaging; vascular biology
资金
- NIH [R01-NS057476, R01-EB001954, R01-NS033335, R01-NS061505, P01NS055104, P50NS010828, K99NS067050]
- AHA [SDG 0835344N, 11IRG5440002]
- AFOSR [MFEL FA9550-07-1-0101]
Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 1339-1345; doi:10.1038/jcbfm.2011.19; published online 2 March 2011
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