期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 31, 期 10, 页码 1986-1998出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2011.107
关键词
image-derived input function; kinetic modeling; neuroreceptor tracers; PET
资金
- National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services (IRP-NIMH-NIH-DHHS)
- National Institute of Mental Health, US [RO1 MH57899]
- National Institute on Aging, US [R01AG031581-10, P30 AG19610]
- state of Arizona
Quantitative positron emission tomography (PET) brain studies often require that the input function be measured, typically via arterial cannulation. Image-derived input function (IDIF) is an elegant and attractive noninvasive alternative to arterial sampling. However, IDIF is also a very challenging technique associated with several problems that must be overcome before it can be successfully implemented in clinical practice. As a result, IDIF is rarely used as a tool to reduce invasiveness in patients. The aim of the present review was to identify the methodological problems that hinder widespread use of IDIF in PET brain studies. We conclude that IDIF can be successfully implemented only with a minority of PET tracers. Even in those cases, it only rarely translates into a less-invasive procedure for the patient. Finally, we discuss some possible alternative methods for obtaining less-invasive input function. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 1986-1998; doi:10.1038/jcbfm.2011.107; published online 3 August 2011
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