期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 31, 期 6, 页码 1475-1481出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2011.11
关键词
aging; gender; imaging; partial volume; receptor; serotonin
资金
- The Lundbeck Foundation, Rigshospitalet
- EU [HEALTH-F5-2007-201380]
- Danish Medical Research Council
Experimental studies indicate that the 5-HT4 receptor activation influence cognitive function, affective symptoms, and the development of Alzheimer's disease (AD). The prevalence of AD increases with aging, and women have a higher predisposition to both AD and affective disorders than men. This study aimed to investigate sex and age effects on 5-HT4 receptor-binding potentials in striatum, the limbic system, and neocortex. Positron-emission tomographic scans were conducted using the radioligand [C-11]SB207145 in a cohort of 30 healthy subjects (mean age 44 years; range 20 to 86 years; 14 men and 16 women). The output parameter, BPND, was modeled using the simplified reference tissue model, and partial volume correction was performed with the Muller-Gartner method. A decline with age of 1% per decade was found only in striatum. Women had a 13% lower 5-HT4 receptor binding in the limbic system. The lower limbic 5-HT4 receptor binding in women supports a role for 5-HT4 receptors in the sex-specific differences in emotional control and might contribute to the higher prevalence of affective diseases and AD in women. The relatively stable 5-HT4 receptor binding with aging contrasts others in subtypes of receptors, which generally decrease with aging. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 1475-1481; doi:10.1038/jcbfm.2011.11; published online 2 March 2011
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