期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 32, 期 1, 页码 6-16出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2011.152
关键词
cortical mapping; electrophysiology; functional MRI; neurovascular coupling; ocular dominance; optical imaging
资金
- NIH [EY11744, DA023002]
- Vanderbilt Vision Research Center
- Vanderbilt University Center for Integrative and Cognitive Neuroscience
The relation of cortical microcirculation, oxygen metabolism, and underlying neuronal network activity remains poorly understood. Anatomical distribution of cortical microvasculature and its relationship to cortical functional domains suggests that functional organizations may be revealed by mapping cerebral blood flow responses. However, there is little direct experimental evidence and a lack of electrophysiological evaluation. In this study, we mapped ocular-dominance columns in primary visual cortex (V1) of anesthetized macaques with capillary flow-based laser speckle contrast imaging and deoxyhemoglobin-based intrinsic optical imaging. In parallel, the local field potentials (LFPs) and spikes were recorded from a linear array of eight microelectrodes, carefully positioned into left and right eye columns in V1. We found differential activation maps of blood flow, after masking large superficial draining vessels, exhibited a column-like pattern similar as the oximetric maps. Both the activated spikes and gamma-band LFP demonstrated corresponding eye preference, consistent with the imaging maps. Our results present direct support in favor of previous proposals that the regulation of microcirculation can be as fine as the submillimeter scale, suggesting that cortical vasculature is functionally organized at the columnar level in a manner appropriate for supplying energy demands of functionally specific neuronal populations. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 6-16; doi:10.1038/jcbfm.2011.152; published online 26 October 2011
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