期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 32, 期 3, 页码 437-442出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2011.178
关键词
dendritic blebbing; hypothermia; in-vivo imaging; ischemia
资金
- Heart and Stroke Foundation of British Columbia
- Heart and Stroke Foundation of Yukon
- Canadian Institutes of Health Research [MOP-111009]
- Human Frontier Science Program
- NSERC
We studied the acute (up to 2 hours after reperfusion) effects of localized cortical hypothermia on ischemia-induced dendritic structural damage. Moderate (31 degrees C) and deep (22 degrees C) hypothermia delays, but does not block the onset of dendritic blebbing or spine loss during global ischemia in mouse in vivo. Hypothermic treatment promoted more consistent recovery of dendritic structure and spines during reperfusion. These results suggest that those using therapeutic hypothermia will need to consider that it does not spare neurons from structural changes that are the result of ischemia, but hypothermia may interact with mechanisms that control the onset of damage and recovery during reperfusion. Journal of Cerebral Blood Flow & Metabolism (2012) 32, 437-442; doi: 10.1038/jcbfm.2011.178; published online 14 December 2011
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