期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 31, 期 1, 页码 58-67出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2010.153
关键词
carbon dioxide; cerebral metabolic rate of oxygen; electroencephalogram; functional connectivity MRI; hypercapnia
资金
- National Institutes of Health [R01 MH084021, R01 NS067015, R01 AG033106, R21 EB007821]
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB007821] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH084021] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS067015] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG033106, R21AG034318] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [ZIADA000469] Funding Source: NIH RePORTER
A better understanding of carbon dioxide (CO2) effect on brain activity may have a profound impact on clinical studies using CO2 manipulation to assess cerebrovascular reserve and on the use of hypercapnia as a means to calibrate functional magnetic resonance imaging (fMRI) signal. This study investigates how an increase in blood CO2, via inhalation of 5% CO2, may alter brain activity in humans. Dynamic measurement of brain metabolism revealed that mild hypercapnia resulted in a suppression of cerebral metabolic rate of oxygen (CMRO2) by 13.4% +/- 2.3% (N = 14) and, furthermore, the CMRO2 change was proportional to the subject's end-tidal CO2 (Et-CO2) change. When using functional connectivity MRI (fcMRI) to assess the changes in resting-state neural activity, it was found that hypercapnia resulted in a reduction in all fcMRI indices assessed including cluster volume, cross-correlation coefficient, and amplitude of the fcMRI signal in the default-mode network (DMN). The extent of the reduction was more pronounced than similar indices obtained in visual-evoked fMRI, suggesting a selective suppression effect on resting-state neural activity. Scalp electroencephalogram (EEG) studies comparing hypercapnia with normocapnia conditions showed a relative increase in low frequency power in the EEG spectra, suggesting that the brain is entering a low arousal state on CO2 inhalation. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 58-67; doi:10.1038/jcbfm.2010.153; published online 15 September 2010
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