期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 30, 期 8, 页码 1412-1431出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2010.66
关键词
animal models; diabetes; hypertension; physiologic control; stroke; vascular variability
资金
- Australian NHMRC Program
- Bethlehem Griffiths and Rebecca Cooper Research Foundations
- MRC Edinburgh Trials Methodology Hub
No single animal model is able to encompass all of the variables known to affect human ischemic stroke. This review highlights the major strengths and weaknesses of the most commonly used animal models of acute ischemic stroke in the context of matching model and experimental aim. Particular emphasis is placed on the relationships between outcome and underlying vascular variability, physiologic control, and use of models of comorbidity. The aim is to provide, for novice and expert alike, an overview of the key controllable determinants of experimental stroke outcome to help ensure the most effective application of animal models to translational research. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1412-1431; doi: 10.1038/jcbfm.2010.66; published online 19 May 2010
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