期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 30, 期 8, 页码 1504-1519出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2010.40
关键词
neurogenesis; plasticity; spreading depression; stroke; vasospasm
资金
- Deutsche Forschungsgemeinschaft (DFG) [DR 323/2-2, 323/5-1]
- Bundesministerium fur Bildung und Forschung [01 EO 0801]
- Kompetenznetz Schlaganfall
- US Army [W81XWH-08-2-0016]
In human cortex it has been suggested that the tissue at risk is indicated by clusters of spreading depolarizations (SDs) with persistent depression of high-frequency electrocorticographic (ECoG) activity. We here characterized this zone in the ET-1 model in rats using direct current (DC)-ECoG recordings. Topical application of the vasoconstrictor endothelin-1 (ET-1) induces focal ischemia in a concentration-dependent manner restricted to a region exposed by a cranial window, while a healthy cortex can be studied at a second naive window. SDs originate in the ET-1-exposed cortex and invade the surrounding tissue. Necrosis is restricted to the ET-1-exposed cortex. In this study, we discovered that persistent depression occurred in both ET-1-exposed and surrounding cortex during SD clusters. However, the ET-1-exposed cortex showed longer-lasting negative DC shifts and limited high-frequency ECoG recovery after the cluster. DC-ECoG recordings of SD clusters with persistent depression from patients with aneurysmal subarachnoid hemorrhage were then analyzed for comparison. Limited ECoG recovery was associated with significantly longer-lasting negative DC shifts in a similar manner to the experimental model. These preliminary results suggest that the ischemic zone in rat and human cortex is surrounded by a normally perfused belt with persistently reduced synaptic activity during the acute injury phase. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 1504-1519; doi: 10.1038/jcbfm.2010.40; published online 24 March 2010
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