期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 30, 期 4, 页码 864-870出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2009.254
关键词
magnetic resonance imaging; SPECT coincidence imaging; tinnitus
资金
- Iran National Science Foundation [84082/07-2005-02-02]
- ENT and Head and Neck Research Center of Iran University of Medical Sciences and Agriculture
- Medical and Industrial Research School [1/4685-2005-01-22]
- National Committee of Ethics in Medical Research [85P/3/315-2006-05-19]
- radiation safety and radioactive drug research committee [317102-2005-10-05]
Tinnitus is often defined as the perception of sounds or noise in the absence of any external auditory stimuli. The pathophysiology of subjective idiopathic tinnitus remains unclear. The aim of this study was to investigate the functional brain activities and possible involved cerebral areas in subjective idiopathic tinnitus patients by means of single photon emission computerized tomography (SPECT) coincidence imaging, which was fused with magnetic resonance imaging (MRI). In this cross-sectional study, 56 patients (1 subject excluded) with subjective tinnitus and 8 healthy controls were enrolled. After intravenous injection of 5mCi F18-FDG (fluorodeoxyglucose), all subjects underwent a brain SPECT coincidence scan, which was then superimposed on their MRIs. In the eight regions of interest (middle temporal, inferotemporal, medial temporal, lateral temporal, temporoparietal, frontal, frontoparietal, and parietal areas), the more pronounced values were represented in medial temporal, inferotemporal, and temporoparietal areas, which showed more important proportion of associative auditory cortices in functional attributions of tinnitus than primary auditory cortex. Brain coincidence SPECT scan, when fused on MRI is a valuable technique in the assessment of patients with tinnitus and could show the significant role of different regions of central nervous system in functional attributions of tinnitus. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 864-870; doi:10.1038/jcbfm.2009.254; published online 13 January 2010
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