期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 29, 期 2, 页码 230-234出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2008.127
关键词
aging; angiogenesis; dopaminergic; exercise; neurodegeneration; neuroprotection
资金
- Spanish Ministry of Education (MEC)
- Spanish Ministry of Health [RD06/0010/0013]
- Galician Government (XUGA)
It is not known if aging induces changes in nigral vascularization and nigral vascular endothelial growth factor ( VEGF) levels similar to those previously reported for Parkinson's disease (PD). In this study nonexercised rats displayed age-dependent decreases in the density of nigral microvessels and VEGF mRNA expression, which were reversed by physical exercise. Such changes may enhance the vulnerability of dopaminergic neurons and the risk of developing PD, and may be reduced by exercise. Furthermore, the observed pattern is the opposite of that previously observed in PD, suggesting that the process underlying PD is not an accelerated age-dependent decline in the dopaminergic system.
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