期刊
NEUROLOGIC CLINICS
卷 33, 期 1, 页码 1-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2014.09.010
关键词
Parkinson disease; alpha-Synuclein; Lewy bodies; Mitochondrial dysfunction
资金
- Leonard Wolfson Experimental Neurology Center
- Wellcome Trust/MRC Joint Call in Neurodegeneration [WT089698]
- Parkinson's UK
- Javon trust
- Kattan Trust
- National Institute for Health Research University College London Hospitals Biomedical Research Centre
The last 2 decades represent a period of unparalleled advancement in the understanding of the pathogenesis of Parkinson disease (PD). The discovery of several forms of familial parkinsonism with mendelian inheritance has elucidated insights into the mechanisms underlying the degeneration of dopaminergic neurons of the substantia nigra that histologically characterize PD. alpha-Synuclein, the principal component of Lewy bodies, remains the presumed pathogen at the heart of the current model; however, concurrently, a diverse range of other mechanisms have been implicated. The creation of a coherent disease model will be crucial to the development of effective disease modifying therapies for sporadic PD.
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