期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 229, 期 7, 页码 834-844出版社
WILEY
DOI: 10.1002/jcp.24510
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资金
- National Natural Science Foundation [81129017, 81202036]
Castration-resistant prostate cancer (CRPC) and its treatment are challenging issues in prostate cancer management. Here, we report that miR-663 is upregulated in CRPC tissues. Overexpression of miR-663 in prostate LNCaP cells promotes cell proliferation and invasion, neuroendocrine differentiation, and reduction in dihydrotestosterone-induced upregulation of prostate-specific antigen expression. Furthermore, results of in situ hybridization show that miR-663 expression is correlated with Gleason score and TNM stage and is an independent prognostic predictor of clinical recurrence. Together, these findings suggest that miR-663 is a potential oncomiR for CRPC and may serve as a tumor biomarker for the early diagnosis of CRPC. J. Cell. Physiol. 229: 834-844, 2014. (c) 2013 Wiley Periodicals, Inc.
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