期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 228, 期 5, 页码 1038-1044出版社
WILEY
DOI: 10.1002/jcp.24251
关键词
-
资金
- Korea government (MEST) [2010-0028236, 2011-0005705, 2012-0005435]
Angiopoietin 1 (Ang1) plays an important role in various endothelial functions, such as vascular integrity and angiogenesis; however, less is known about its function outside of the endothelium. In this study, we examined whether Ang1 has direct effects on skeletal muscle cells. We found that Ang1 exhibited myogenic potential, as it promoted the proliferation, migration, and differentiation of mouse primary skeletal myoblasts. The positive effect of Ang1 on myoblast proliferation could have been mediated by the a7 and beta 1 integrins. We also found that Ang1 potentiated cellular Ca2+ movements in differentiated myotubes in response to stimuli, possibly through the increased expression of two Ca2+-related proteins, namely, Orai1 and calmodulin. Ang1 also increased Orai1 and calmodulin expression in mouse hearts in vivo. These results provide an insight into the molecular mechanisms by which Ang1 directly affects the myogenesis of striated muscle. J. Cell. Physiol. (C) 2012 Wiley Periodicals, Inc.
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