期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 228, 期 4, 页码 860-870出版社
WILEY
DOI: 10.1002/jcp.24236
关键词
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资金
- FONDECYT [1095075, 1101012]
- FONDAP [15090007]
- UNAB [DI-02-11/N]
- CONICYT
- MECESUP
Transient Receptor Potential Vanilloid type 1 channel (TRPV1) is an important endogenous transducer of noxious heat and chemical stimuli and is required during development of inflammatory hypersensitivity. The transcription factor Runx1 is known to play a relevant role in sensory neuron differentiation as it controls the expression of several sensory nociceptive receptors, including TRPV1. Here, we show that Runx1 up-regulates TRPV1 transcription activity by interacting directly with the proximal TRPV1 gene promoter sequence. Importantly, C/EBP beta a well-established heterodimer partner of Runx1 also binds to the TRPV1 promoter and cooperates with Runx1 to further stimulate TRPV1 transcription. Our results support a mechanism where Runx1-C/EBP beta-containing transcription regulatory complexes are recruited to the TRPV1 gene promoter to modulate TRPV1 expression in dorsal root ganglia neurons. J. Cell. Physiol. 228: 860870, 2013. (c) 2012 Wiley Periodicals, Inc.
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