期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 227, 期 6, 页码 2421-2429出版社
WILEY-BLACKWELL
DOI: 10.1002/jcp.22977
关键词
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资金
- National Science Fund for Distinguished Young Scholars [30625034]
- National Natural Science Foundation of China [30900757, 30800513]
- Natural Science Foundation of Shanghai Municipality [09ZR1418300]
- Shanghai Municipal Education Commission
- Shanghai Education Development Foundation [09CG13]
- Science and Technology Commission of Shanghai Municipality [10QA1404400]
Although the two isoforms of signal transducer and activator of transcription 5 (STAT5) protein, STAT5a and STAT5b, have 94% sequence identity, they are encoded by different genes. Previous studies have been unable to define clearly the roles of the STAT5 genes in colorectal cancer (CRC). To investigate the role of STAT5 isoforms in CRC oncogenesis, immunohistochemical staining was performed. Colorectal adenocarcinomas showed higher expression of STAT5a/5b than normal colonic mucosa (P?
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