期刊
JOURNAL OF CELLULAR PHYSIOLOGY
卷 226, 期 11, 页码 3043-3052出版社
WILEY-BLACKWELL
DOI: 10.1002/jcp.22652
关键词
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资金
- FONDECYT [1095075]
- FONDAP [15090007]
- NIH [PO1 AR48818]
- CONICYT
The Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by key regulators of osteoblast differentiation including homeodomain factors and Wnt- and BMP-signaling mediators. Here, we report that the transcription factor C/EBP beta up-regulates Runx2/p57 expression by directly binding to the Runx2 P1 promoter in mesenchymal, pre-osteoblastic, and osteoblastic cells. This C/EBP beta-mediated up-regulation is principally dependent on C/EBP site II that is located within the first 180 bp of the proximal P1 promoter region and is highly conserved among mouse, rat, and human Runx2 genes. Our studies reveal how the C/EBPb factor, known to have a key role during osteogenesis, contributes to regulating the expression of Runx2, the master regulator of osteoblast differentiation. J. Cell. Physiol. 226: 3043-3052, 2011. (C) 2011 Wiley-Liss, Inc.
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