期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 120, 期 2, 页码 1685-1693出版社
WILEY
DOI: 10.1002/jcb.27478
关键词
apoptosis; calcium ionophore A23187; calpain inhibitor; endoplasmic reticulum stress; hepatic fibrosis; hepatic stellate cells
资金
- Natural Science Foundation of Hebei Province Plan [H2015209043]
We previously showed that changes in calcium concentrations were related to cell apoptosis in vitro. The endoplasmic reticulum (ER) is the main component of calcium storage and signal transduction, and disrupting the balance of intracellular Ca2+ can cause endoplasmic reticulum stress (ERS). In this process, the ER releases stored Ca (2+) into the cytoplasm and activates calpain-2. To further investigate the effect of calpain in hepatic stellate cells (HSCs), in the current study, we examine the effect of N-acetyl-leu-leu-norleucinal (ALLN) on apoptosis resulting from calcium ionophore A23187-induced ERS. Our findings indicate that calpain inhibition reduces calcium ionophore A23187-induced apoptosis of HSCs and decreases the expression of ER stress proteins that may be related to the calpain/caspase signaling pathway.
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