期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 113, 期 10, 页码 3061-3068出版社
WILEY
DOI: 10.1002/jcb.24183
关键词
INDUCED PLURIPOTENT STEM CELLS; REPROGRAMMING METHODS; TRANSLATIONAL MEDICINE
资金
- Intramural NIH HHS [ZIA AR041193-02] Funding Source: Medline
The discovery of the ability to induce somatic cells to a pluripotent state through the overexpression of specific transcription factors has the potential to transform the ways in which pharmaceutical agents and cellular transplantation therapies are developed. Proper utilization of the technology to generate induced pluripotent stem cells (iPSCs) requires that researchers select the appropriate reprogramming method for generating iPSCs so that the resulting iPSCs can be transitioned towards clinical applications effectively. This article reviews all of the currently available reprogramming techniques with a focus on critiquing them on the basis of their utility in translational medicine. J. Cell. Biochem. 113: 3061-3068, 2012. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
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