期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 113, 期 3, 页码 742-751出版社
WILEY
DOI: 10.1002/jcb.23424
关键词
Rad9; ONCOGENE; TUMOR SUPPRESSOR; CELL CYCLE CHECKPOINT; DNA REPAIR
资金
- National Institutes of Health [5R01CA130536-17, 5R01GM079107-10, 5P01CA49062-20]
Rad9 plays a crucial role in maintaining genomic stability by regulating cell cycle checkpoints, DNA repair, telomere stability, and apoptosis. Rad9 controls these processes mainly as part of the heterotrimeric 9-1-1 (Rad9-Hus1-Rad1) complex. However, in recent years it has been demonstrated that Rad9 can also act independently of the 9-1-1 complex as a transcriptional factor, participate in immunoglobulin class switch recombination, and show 3'-5' exonuclease activity. Aberrant Rad9 expression has been associated with prostate, breast, lung, skin, thyroid, and gastric cancers. High expression of Rad9 is causally related to, at least, human prostate cancer growth. On the other hand, deletion of Mrad9, the mouse homolog, is responsible for increased skin cancer incidence. These results reveal that Rad9 can act as an oncogene or tumor suppressor. Which of the many functions of Rad9 are causally related to initiation and progression of tumorigenesis and the mechanistic details by which Rad9 induces or suppresses tumorigenesis are presently not known, but are crucial for the development of targeted therapeutic interventions. J. Cell. Biochem. 113: 742751, 2012. (C) 2011 Wiley Periodicals, Inc.
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