期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 113, 期 6, 页码 2040-2046出版社
WILEY
DOI: 10.1002/jcb.24075
关键词
CARDIAC HYPERTROPHY; microRNA; miR-221; p27
资金
- Ministry of Science and Technology of China [2007DFC30340]
- National Natural Science Foundation of China [81070100]
Cardiac hypertrophy has been known as an independent predictor for cardiovascular morbidity and mortality. Molecular mechanisms underlying the development of heart failure remain elusive. Recently, microRNAs (miRs) have been established as important regulators in cardiac hypertrophy. Here, we reported miR-221 was up-regulated in both transverse aortic constricted mice and patients with hypertrophic cardiomyopathy (HCM). Forced expression of miR-221 by transfection of miR-221 mimics increased myocyte cell size and induced the re-expression of fetal genes, which were inhibited by the knockdown of endogenous miR-221 in cardiomyocytes. The TargetScan algorithm-based prediction identified that p27, a cardiac hypertrophic suppressor, is the putative target of miR-221, which was confirmed by luciferase assay and Western blotting.
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