期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 112, 期 9, 页码 2549-2557出版社
WILEY
DOI: 10.1002/jcb.23179
关键词
IL-8; MIGRATION; CHONDROSARCOMA; INTEGRIN; AP-1
资金
- National Science Council of Taiwan [NSC99-2628-B-002-025-MY3, NSC99-2628-B-002-014-MY3]
- China Medical University [CMU99-ASIA-10]
Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs. Interleukin-8 (IL-8), a chemokine with a defining CXC amino acid motif, is known to possess tumorigenic and proangiogenic properties. Over-expression of IL-8 has been detected in many human tumors. However, the effects of IL-8 in migration and integrin expression in chondrosarcoma cells are largely unknown. In this study, we found that IL-8 increased the migration and the expression of alpha v beta 3 integrin in human chondrosarcoma cells. Activations of phosphatidylinositol 3-kinase (PI3K), Akt, and AP-1 pathways after IL-8 treatment were demonstrated, and IL-8-induced expression of integrin and migration activity was inhibited by the specific inhibitor and mutant of PI3K, Akt, and AP-1 cascades. Taken together, our results indicated that IL-8 enhances the migration of chondrosarcoma cells by increasing alpha v beta 3 integrin expression through the PI3K/Akt/AP-1 signal transduction pathway. J. Cell. Biochem. 112: 2549-2557, 2011. (C) 2011 Wiley-Liss, Inc.
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