期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 112, 期 7, 页码 1930-1937出版社
WILEY-BLACKWELL
DOI: 10.1002/jcb.23113
关键词
MULTIPLE SCLEROSIS; 2-D DIGE; CEREBROSPINAL FLUID; COMPLEMENT
资金
- Natural Science Foundation of China [81070952]
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with complex immunopathogenesis. Using the 2-D DIGE technology, we separate CSF proteins from patients with active MS and control subjects. Three of the seven differential proteins identified were related with complement system, and the network analysis of the differential proteins revealed complement activation involvement in active MS. Complement C4b (gamma chain) was confirmed elevated by performing western blotting analysis (P < 0.01). The present results are an independent quantitative proteomic measure in CSF from active MS patients. The differential expression of the complement C4b and related proteins in CSF provides potential biomarkers as well as evidence for the involvement of complement activation in the pathogenesis of MS disease. J. Cell. Biochem. 112: 1930-1937, 2011. (C) 2011 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据