期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 112, 期 11, 页码 3482-3488出版社
WILEY-BLACKWELL
DOI: 10.1002/jcb.23279
关键词
SAITOHIN INTERACTIONS; PRIMATE-SPECIFIC GENE; HUMAN-SPECIFIC ALLELE; MAP TAU; TYROSINE KINASE Abl; ALLELE-SPECIFIC EFFECTS; NEURODEGENERATION
资金
- NIA [R01 AG018486, R21 AG028534]
- Rosalinde and Arthur Gilbert Foundation/AFAR New Investigator Award in Alzheimer's Disease
- Taub Institute for Research on Alzheimer's Disease and the Aging Brain
- Columbia University
Saitohin (STH) is a gene unique to humans and their closest relatives whose function is not yet known. STH contains a single polymorphism (Q7R); the Q allele is human-specific and confers susceptibility to several neurodegenerative diseases. In previous work, we discovered that STH interacts with Peroxiredoxin 6 (Prdx6), a unique member of that family which is bifunctional and whose levels increase in Pick's disease. In this study, we report that STH also interacts with tau and the non-receptor tyrosine kinase c-Abl (Abl). Furthermore, Abl phosphorylates STH on its single tyrosine residue and STH increases tyrosine phosphorylation by Abl. The effect of Saitohin on Abl-mediated phosphorylation appears to be allele-specific, providing evidence for a new cellular function for STH. J. Cell. Biochem. 112: 3482-3488, 2011. (C) 2011 Wiley Periodicals, Inc.
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