期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 112, 期 6, 页码 1486-1490出版社
WILEY-BLACKWELL
DOI: 10.1002/jcb.23085
关键词
HEMATOPOIETIC STEM CELL; MICROENVIRONMENT; NICHE
资金
- Swedish Research Council
- Swedish Tegger Foundation
- NHMRC
- Baker Foundation
- Association for International Cancer Research
- Leukaemia Foundation
Understanding the in vivo regulation of hematopoietic stem cells (HSCs) will be critical to identifying key factors involved in the regulation of HSC self-renewal and differentiation. The niche (microenvironment) in which HSCs reside has recently regained attention accompanied by a dramatic increase in the understanding of the cellular constituents of the bone marrow HSC niche. The use of sophisticated genetic models allowing modulation of specific lineages has demonstrated roles for mesenchymal-derived elements such as osteoblasts and adipocytes, vasculature, nerves, and a range of hematopoietic progeny of the HSC as being participants in the regulation of the bone marrow microenvironment. Whilst providing significant insight into the cellular composition of the niche, is it possible to manipulate any given cell lineage in vivo without impacting, knowingly or unknowingly, on those that remain? J. Cell. Biochem. 112: 1486-1490, 2011. (C) 2011 Wiley-Liss, Inc.
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