期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 112, 期 2, 页码 401-408出版社
WILEY-BLACKWELL
DOI: 10.1002/jcb.22970
关键词
ESTROGEN; ANDROGEN; BONE; TRANSCRIPTION; STEROID HORMONES
资金
- NIH/ORWH [1R56DK090231-01, K12 BIRCWH, HD001400-08]
The sex steroid hormones, androgens and estrogens, via their respective nuclear receptors, regulate bone mineral density in humans and mice. Very little is known about the direct targets of the androgen and estrogen receptors in bone cells. First, models of hormone and receptor deficiency in mouse and human bone are discussed. This review then focuses on the direct targets of the receptors in osteoblasts and osteoclasts. A direct target of a NR is defined here as a gene that is regulated by NR binding to the DNA (either through DNA binding or association with a DNA binding protein) at an enhancer or promoter of that gene. The experimental evidence that illustrates androgen and estrogen gene regulation in osteoblasts and osteoclasts will be summarized and compared with the phenotype of the hormones in vivo. J. Cell. Biochem. 112: 401-408, 2011. (C) 2011 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据