期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 112, 期 10, 页码 2688-2693出版社
WILEY-BLACKWELL
DOI: 10.1002/jcb.23218
关键词
MYCOBACTERIUM TUBERCULOSIS; PHAGOLYSOSOME; SECRETORY EFFECTOR; DRUG TARGET
资金
- National Key Infectious Disease Project [2008ZX10003-006, 2008ZX10003-001]
- Southwest University [kb2009010, ky2009009]
- Fundamental Research Funds for the Central Universities [XDJK2009A003]
- Natural Science Foundation of CQ CSTC [2010BB5002]
- National Natural Science Foundation of China [81071316]
Tuberculosis remains a serious global health threat with nearly 10 million new cases and 1.7 million deaths every year. The emergence of multi-drug resistant (MDR) and extensively drug resistant (XDR) strains of Mycobacterium tuberculosis (Mtb) further complicates this problem. It is pressing to find new ways to combat Mtb. The success of Mtb is largely attributed to its ability to persist within macrophages by arresting phagosomal maturation. The bacterial proteins and lipids play important roles in this inhibition which involves several aspects of phagosomal maturation, including both fusion and fission events and recruitment of V-ATPases allowing acidification. Understanding the interaction between the pathogen and host macrophage is essential to eradicate or control tuberculosis. This review focuses on the mechanism of phagolysosome formation, the pivotal event for the fates of infection participants and abundance of novel drug targets. J. Cell. Biochem. 112: 2688-2693, 2011. (C) 2011 Wiley-Liss, Inc.
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