期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 111, 期 1, 页码 59-66出版社
WILEY
DOI: 10.1002/jcb.22662
关键词
INVADOPODIA; MIGRATION; INVASION; Tm4SF5; MMP; METASTASIS
资金
- Korea Ministry of Education, Science and Technology [R13-2007-019-00000-0]
- MOEHRD Basic Research Promotion Fund [KRF-2007-000186]
- Research Program for New Drug Target Discovery [2007-03536]
- Cell Dynamics Research Center, KOSEF, South Korea [R11-2007-007-01004-0]
- National Research Foundation of Korea [R11-2007-007-01004-0, 2007-03536] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Overexpression of transmembrane 4 L SIX family member 5 (TM4SF5), a four-transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of TM4SF5 in migration, invasion. and tumor metastasis remain unknown Using in vitro hepatocarcinoma cells that ectopically or endogenously express TM4SF5 and in vivo mouse systems, roles of TM4SF5 in metastatic potentials were examined We found that TM4SF5 expression facilitated migration, invadopodia formation. MMP activation, invasion, and eventually lung metastasis in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects Altogether, TM4SF5-mediated migration and invasion suggest that TM4SF5 may be therapeutically targeted to deal with TM4SF5-mediated hepatocellular cancers J. Cell. Biochem. 111: 59-66, 2010 (C) 2010 Wiley-Liss. Inc
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