期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 111, 期 5, 页码 1087-1098出版社
WILEY
DOI: 10.1002/jcb.22913
关键词
PRL-3 PHOSPHATASE; CANCER METASTASIS; CANCER CELL SIGNALING
The deregulated expression of members of the phosphatase of regenerating liver (PRL) family has been implicated in the metastatic progression of multiple human cancers. Importantly, PRL-1 and PRL-3 both possess the capacity to drive key steps in metastatic progression. Yet, little is known about the regulation and oncogenic mechanisms of this emerging class of dual-specificity phosphatases. This prospect article details the involvement of PRLs in the metastatic cascade, the regulatory mechanisms controlling PRL expression, and recent efforts in the characterization of PRL-modulated pathways and substrates using biochemical and high-throughput approaches. Current advances and future prospects in anti-cancer therapy targeting this family are also discussed. J. Cell. Biochem. 111: 1087-1098, 2010. (C) 2010 Wiley-Liss, Inc.
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