期刊
NEUROIMAGE
卷 120, 期 -, 页码 362-370出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.07.016
关键词
Uncertainty; Prediction; Mismatch; Novelty; Theta entrainment; Hippocampus; Connectivity; MEG; Ventromedial prefrontal cortex
资金
- Australian Research Council Discovery Early Career Researcher Award [DE130101393]
- Australian Research Council Centre of Excellence for Integrative Brain Function (ARC Centre Grant) [CE140100007]
- Wellcome Trust [085316/Z/08/Z]
- MRC UK MEG Partnership Grant [MR/K005464/1]
- Wellcome Trust Fellowship [WT085189MA]
- Wellcome Trust Principal Research Fellowship [101759/Z/13/Z]
- Wellcome Trust [085316/Z/08/Z] Funding Source: Wellcome Trust
- MRC [MR/K005464/1, G1002276] Funding Source: UKRI
- Medical Research Council [MR/K005464/1, G1002276] Funding Source: researchfish
- Australian Research Council [DE130101393] Funding Source: Australian Research Council
Detecting environmental change is fundamental for adaptive behavior in an uncertain world. Previous work indicates the hippocampus supports the generation of novelty signals via implementation of a match-mismatch detector that signals when an incoming sensory input violates expectations based on past experience. While existing work has emphasized the particular contribution of the hippocampus, here we ask which other brain structures also contribute to match-mismatch detection. Furthermore, we leverage the fine-grained temporal resolution of magnetoencephalography (MEG) to investigate whether mismatch computations are spectrally confined to the theta range, based on the prominence of this range of oscillations in models of hippocampal function. By recording MEG activity while human subjects performa task that incorporates conditions of match-mismatch novelty we show that mismatch signals are confined to the theta band and are expressed in both the hippocampus and ventromedial prefrontal cortex (vmPFC). Effective connectivity analyses (dynamic causal modeling) show that the hippocampus and vmPFC work as a functional circuit during mismatch detection. Surprisingly, our results suggest that the vmPFC drives the hippocampus during the generation and processing of mismatch signals. Our findings provide new evidence that the hippocampal-vmPFC circuit is engaged during novelty processing, which has implications for emerging theories regarding the role of vmPFC in memory. (C) 2015 The Authors. Published by Elsevier Inc.
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