期刊
NEUROIMAGE
卷 112, 期 -, 页码 152-159出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.03.002
关键词
-
资金
- National Institutes on Aging [R01AG036921]
Knowledge of online functional brain mechanisms of locomotion is scarce due to technical limitations of traditional neuroimaging methods. Using functional Near Infrared Spectroscopy (fNIRS) we evaluated task-related changes in oxygenated hemoglobin levels (HbO(2)) in real-time over the pre-frontal-cortex (PFC) regions during simple (Normal Walk; NW) and attention-demanding (Walking While Talking; WWT) locomotion tasks in a large cohort of non-demented older adults. Results revealed that the assessment of task-related changes in HbO(2) was internally consistent. Imposing greater demands on the attention system during locomotion resulted in robust bilateral PFC increases in HbO(2) levels during WWT compared to NW and the cognitive interference tasks. Elevated PFC oxygenation levels were maintained throughout the course of WWT but not during the NW condition. Increased oxygenation levels in the PFC were related to greater stride length and better cognitive performance but not to faster gait velocity in WWT. These findings elucidate online brain mechanisms of locomotion, and confer significant implications for risk assessment and intervention for major mobility outcomes. (C) 2015 Elsevier Inc. All rights reserved.
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