期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 108, 期 5, 页码 1153-1165出版社
WILEY
DOI: 10.1002/jcb.22344
关键词
PLATELET RICH PLASMA; CHONDROCYTE; GROWTH FACTORS; PROTEOME; TISSUE ENGINEERING
资金
- Fondazione Monte dei Paschi di Siena
- Toscana Life Sciences Foundation
The aim of the present study was to demonstrate the mitogenic and differentiating properties of platelet-rich plasma releasates (PRPr) on human chondrocytes in mono- and three-dimensional cultures. In order to assess if PRPr supplementation could maintain the chondrocyte phenotype or at least inhibit the cell de-differentiation even after several clays in culture, we performed a proteomic study on several cell cultures independently grown, for different periods of time, in culture medium with FCS, human serum (HS), and releasates obtained from PRP and platelet-poor plasma (PPP). We found that PRP treatment actually induced in chondrocytes the expression of proteins (some of which novel) involved in differentiation. J. Cell. Biochem. 108: 1153-1165, 2009. (C) 2009 Wiley-Liss, Inc.
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