期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 22, 期 10, 页码 4617-4629出版社
WILEY
DOI: 10.1111/jcmm.13797
关键词
extracellular histones; immunothrombosis; inflammation; innate immunity
资金
- Royal College of Surgeons of England Research Fellowship
- UK/China Postgraduate Scholarship for Excellence
- Medical Research Council
- National Institute for Health Research
Histones are positively charged nuclear proteins that facilitate packaging of DNA into nucleosomes common to all eukaryotic cells. Upon cell injury or cell signalling processes, histones are released passively through cell necrosis or actively from immune cells as part of extracellular traps. Extracellular histones function as microbicidal proteins and are pro-thrombotic, limiting spread of infection or isolating areas of injury to allow for immune cell infiltration, clearance of infection and initiation of tissue regeneration and repair. Histone toxicity, however, is not specific to microbes and contributes to tissue and end-organ injury, which in cases of systemic inflammation may lead to organ failure and death. This review details the processes of histones release in acute inflammation, the mechanisms of histone-related tissue toxicity and current and future strategies for therapy targeting histones in acute inflammatory diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据