期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 22, 期 10, 页码 5121-5131出版社
WILEY
DOI: 10.1111/jcmm.13801
关键词
NF-kappa B; osteoclast; osteoporosis; tectorigenin
资金
- National Natural Science Foundation of China [81572173, 81371996, 81401824]
- Natural Science Foundation of Zhejiang Province [Y14H060014, Y17H060027]
Metabolism of bone is regulated by the balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Activation of osteoclasts could lead to osteoporosis. Thus, inhibiting the activity of osteoclasts becomes an available strategy for the treatment of osteoporosis. Tectorigenin is an extract of Belamcanda chinensis In the present study, the anti-osteoclastogenesis effects of tectorigenin were investigated in vitro and in vivo. The results showed preventive and therapeutic effects of tectorigenin at concentrations of 0, 10, 40, and 80 mu mol/L in the maturation and activation of osteoclasts. A signalling study also indicated that tectorigenin treatment reduces activation of NF-kappa B signalling in osteoclastogenesis. Animal experiment demonstrated that tectorigenin treatment (1-10 mg/kg, abdominal injection every 3 days) significantly inhibits bone loss in ovariectomized C57BL/6. Our data suggest that tectorigenin is a potential pharmacological choice for osteoporosis.
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