期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 22, 期 11, 页码 5196-5207出版社
WILEY
DOI: 10.1111/jcmm.13835
关键词
mesenchymal stem cell; multilineage; reactive oxygen species; regenerative medicine; self-renewal
资金
- China Postdoctoral Science Foundation [2017M183789]
- Stem Cell and Translational Research, the National Key Research and Development Program of China [2016YFA0101001]
- National Natural Science Foundation of China [81700553]
Mesenchymal stem cells (MSCs) are broadly used in cell-based regenerative medicine because of their self-renewal and multilineage potencies invitro and invivo. To ensure sufficient amounts of MSCs for therapeutic purposes, cells are generally cultured invitro for long-term expansion or specific terminal differentiation until cell transplantation. Although physiologically up-regulated reactive oxygen species (ROS) production is essential for maintenance of stem cell activities, abnormally high levels of ROS can harm MSCs both invitro and invivo. Overall, additional elucidation of the mechanisms by which physiological and pathological ROS are generated is necessary to better direct MSC fates and improve their therapeutic effects by controlling external ROS levels. In this review, we focus on the currently revealed ROS generation mechanisms and the regulatory routes for controlling their rates of proliferation, survival, senescence, apoptosis, and differentiation. A promising strategy in future regenerative medicine involves regulating ROS generation via various means to augment the therapeutic efficacy of MSCs, thus improving the prognosis of patients with terminal diseases.
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