期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 18, 期 5, 页码 749-758出版社
WILEY
DOI: 10.1111/jcmm.12270
关键词
type 1 diabetes; autoimmune disease; T lymphocyte; islet cells; immunological mechanism
资金
- Youth Foundation of Zhongshan Hospital, Fudan University [2013ZSQN23]
Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of insulin-producing pancreatic cells. In recent years, the incidence of type 1 diabetes continues to increase. It is supposed that genetic, environmental and immune factors participate in the damage of pancreatic cells. Both the immune regulation and the immune response are involved in the pathogenesis of type 1 diabetes, in which cellular immunity plays a significant role. For the infiltration of CD4(+) and CD8(+) T lymphocyte, B lymphocytes, natural killer cells, dendritic cells and other immune cells take part in the damage of pancreatic cells, which ultimately lead to type 1 diabetes. This review outlines the cellular immunological mechanism of type 1 diabetes, with a particular emphasis to T lymphocyte and natural killer cells, and provides the effective immune therapy in T1D, which is approached at three stages. However, future studies will be directed at searching for an effective, safe and long-lasting strategy to enhance the regulation of a diabetogenic immune system with limited toxicity and without global immunosuppression.
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