期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 19, 期 1, 页码 249-256出版社
WILEY
DOI: 10.1111/jcmm.12433
关键词
adult stem cells; endometrium; mesenchymal stem cells; MPTP; neurodegenerative diseases; Parkinson disease; stem cells; transplantation
资金
- National Institutes of Health, USA [NIH U54 HD052668]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [U54HD052668] Funding Source: NIH RePORTER
Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. Cell-replacement therapies have emerged as a promising strategy to slow down or replace neuronal loss. Compared to other stem cell types, endometrium-derived stem cells (EDSCs) are an attractive source of stem cells for cellular therapies because of their ease of collection and vast differentiation potential. Here we demonstrate that endometrium-derived stem cells may be transplanted into an MPTP exposed monkey model of PD. After injection into the striatum, endometrium-derived stem cells engrafted, exhibited neuron-like morphology, expressed tyrosine hydroxylase (TH) and increased the numbers of TH positive cells on the transplanted side and dopamine metabolite concentrations in vivo. Our results suggest that endometrium-derived stem cells may provide a therapeutic benefit in the primate model of PD and may be used in stem cell based therapies.
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