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Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission
Heather A. Hirsch et al.
CANCER RESEARCH (2009)
The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
John M. Heddleston et al.
CELL CYCLE (2009)
Prognostic relevance of hypoxia inducible factor-1 alpha expression in patients with melanoma
J. Valencak et al.
CLINICAL AND EXPERIMENTAL DERMATOLOGY (2009)
Melanoma epidemiology and trends
Claus Garbe et al.
CLINICS IN DERMATOLOGY (2009)
Mechanisms of bone metastases of breast cancer
Larry J. Suva et al.
ENDOCRINE-RELATED CANCER (2009)
The Akt/mTOR Pathway Assures the Synthesis of HIF-1α Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors
Hiroshi Harada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
BCL-xL Is a Target Gene Regulated by Hypoxia-inducible Factor-1α
Ni Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Endothelial NOS, estrogen receptor β, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer
Simona Nanni et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Expression and function of hypoxia inducible factor-1 alpha in human melanoma under non-hypoxic conditions
Caroline N. Mills et al.
MOLECULAR CANCER (2009)
Therapeutic Inhibition of the Epidermal Growth Factor Receptor in High-Grade Gliomas: Where Do We Stand?
Georg Karpel-Massler et al.
MOLECULAR CANCER RESEARCH (2009)
NF-κB Activation, Dependent on Acetylation/Deacetylation, Contributes to HIF-1 Activity and Migration of Bone Metastatic Breast Carcinoma Cells
Paola Bendinelli et al.
MOLECULAR CANCER RESEARCH (2009)
Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells
Hongbo Hu et al.
MOLECULAR CANCER THERAPEUTICS (2009)
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Chen Zhao et al.
NATURE (2009)
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
A. Soeda et al.
ONCOGENE (2009)
Hypoxia and TGF-β Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Cells and the Bone Microenvironment
Lauren K. Dunn et al.
PLOS ONE (2009)
Multiple Lineages of Human Breast Cancer Stem/Progenitor Cells Identified by Profiling with Stem Cell Markers
Wendy W. Hwang-Verslues et al.
PLOS ONE (2009)
Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations
Cameron Brennan et al.
PLOS ONE (2009)
被撤回的出版物: Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells (Retracted article. See vol. 119, 2022)
KangAe Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells
Amalia Azzariti et al.
BIOCHEMICAL PHARMACOLOGY (2008)
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
Eiji Furuta et al.
CANCER RESEARCH (2008)
Targeting cancer stem cells through L1CAM suppresses glioma growth
Shideng Bao et al.
CANCER RESEARCH (2008)
Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma
Luigi Strizzi et al.
CELL CYCLE (2008)
Role and regulation of prolyl hydroxylase domain proteins
G-H Fong et al.
CELL DEATH AND DIFFERENTIATION (2008)
Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor
Xianhua Cao et al.
CLINICAL CANCER RESEARCH (2008)
Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer
M. Mimeault et al.
GUT (2008)
CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone
Sreenivasa R. Chinni et al.
MOLECULAR CANCER RESEARCH (2008)
Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype
Borhane Annabi et al.
MOLECULAR CANCER RESEARCH (2008)
Identification of cells initiating human melanomas
Tobias Schatton et al.
NATURE (2008)
Direct regulation of TWIST by HIF-1α promotes metastasis
Muh-Hwa Yang et al.
NATURE CELL BIOLOGY (2008)
c-Myc Is Required for Maintenance of Glioma Cancer Stem Cells
Jialiang Wang et al.
PLOS ONE (2008)
Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells
Angela Colmone et al.
SCIENCE (2008)
Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
Bikul Das et al.
STEM CELLS (2008)
Antitumor activity of rapamycin in a phase I trial for patients with recurrent PTEN-Deficient glioblastoma
Tim F. Cloughesy et al.
PLOS MEDICINE (2008)
Influence of oxygen tension on CD133 phenotype in human glioma cell cultures
Nadine Platet et al.
CANCER LETTERS (2007)
PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis
Jing Fang et al.
CELLULAR SIGNALLING (2007)
Malignant astrocytic glioma: genetics, biology, and paths to treatment
Frank B. Furnari et al.
GENES & DEVELOPMENT (2007)
TGF-β and BMP7 interactions in tumour progression and bone metastasis
Jeroen T. Buijs et al.
CLINICAL & EXPERIMENTAL METASTASIS (2007)
Advances in counselling and surveillance patients at risk for pancreatic cancer
Randall E. Brand et al.
GUT (2007)
Hypoxia enhances metastatic efficiency in HT1080 fibrosarcorna cells by increasing cell survival in lungs, not cell adhesion and invasion
Li Zhang et al.
CANCER RESEARCH (2007)
Current concepts: Local therapy and survival in breast cancer
Rinaa S. Punglia et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
Chronic myeloid leukaemia as a model of disease evolution in human cancer
Junia V. Melo et al.
NATURE REVIEWS CANCER (2007)
HIF-2α promotes hypoxic cell proliferation by enhancing c-Myc transcriptional activity
John D. Gordan et al.
CANCER CELL (2007)
Mutant V600E BRAF increases hypoxia inducible factor-1α expression in melanoma
Suresh M. Kumar et al.
CANCER RESEARCH (2007)
Molecular definition of breast tumor heterogeneity
Michail Shipitsin et al.
CANCER CELL (2007)
Serum macrophage inhibitory cytokine-1 concentrations correlate with the presence of prostate cancer bone metastases
Katri S. Selander et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2007)
Melanoma biology and new targeted therapy
Vanessa Gray-Schopfer et al.
NATURE (2007)
A perivascular niche for brain tumor stem cells
Christopher Calabrese et al.
CANCER CELL (2007)
Daoy medulloblastoma cells that express CD133 are radioresistant relative to CD133- cells, and the CD133+ sector is enlarged by hypoxia
Ed R. Blazek et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)
Renal cancer cells lacking hypoxia inducible factor (HIF)-1 alpha expression maintain vascular endothelial growth factor expression through HIF-2 alpha
Toshiaki Shinojima et al.
CARCINOGENESIS (2007)
Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
Elena Monzani et al.
EUROPEAN JOURNAL OF CANCER (2007)
Stem cells: A revolution in therapeutics - Recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies
M. Mimeault et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
Recent advances in cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers
M. Mimeault et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2007)
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao et al.
NATURE (2006)
Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice
Yiguo Hu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
Mahvash Zakikhani et al.
CANCER RESEARCH (2006)
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma:: HIF-2α promotes an aggressive phenotype
Linda Holmquist-Mengelbier et al.
CANCER CELL (2006)
Signaling pathways in self-renewing hematopoietic and leukemic stem cells: do all stem cells need a niche?
Aleksandra Rizo et al.
HUMAN MOLECULAR GENETICS (2006)
Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1α signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
Xiang-Hong Peng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor
Shideng Bao et al.
CANCER RESEARCH (2006)
Chemotherapy resistance of glioblastoma stem cells
A. Eramo et al.
CELL DEATH AND DIFFERENTIATION (2006)
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
Moshe Talpaz et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition -: The role of HIF-1α, HIF-2α, and other pathways
Gareth P. Elvidge et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms
Therese Sorlie et al.
BMC GENOMICS (2006)
The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1α-dependent mechanism
MS Ullah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Adding chloroquine to conventional treatment for glioblastoma multiforme -: A randomized, double-blind, placebo-controlled trial
J Sotelo et al.
ANNALS OF INTERNAL MEDICINE (2006)
Proliferating cell nuclear antigen, survivin, and CD34 expressions in pancreatic cancer and their correlation with hypoxia-inducible factor 1α
Haiyan Wei et al.
PANCREAS (2006)
HIF-2α regulates Oct-4:: effects of hypoxia on stem cell function, embryonic development, and tumor growth
KL Covello et al.
GENES & DEVELOPMENT (2006)
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
JA Burger et al.
BLOOD (2006)
Small interfering RNA expression vector targeting hypoxia-inducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers
T Mizuno et al.
CANCER GENE THERAPY (2006)
MITF: master regulator of melanocyte development and melanoma oncogene
Carmit Levy et al.
TRENDS IN MOLECULAR MEDICINE (2006)
CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: The role of bone microenvironment-associated CXCL12
SR Chinni et al.
PROSTATE (2006)
Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies
M Mimeault et al.
PANCREAS (2005)
A tumorigenic subpopulation with stem cell properties in melanomas
D Fang et al.
CANCER RESEARCH (2005)
Cripto-1: A multifunctional modulator during embryogenesis and oncogenesis
L Strizzi et al.
ONCOGENE (2005)
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
Q Xu et al.
ONCOGENE (2005)
Hypoxia-inducible factor 1α is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells
R Buscà et al.
JOURNAL OF CELL BIOLOGY (2005)
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1α
RJ Phillips et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
R Stupp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo
YX Sun et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2005)
The mammalian basic helix-loop-helix/PAS family of transcriptional regulators
RJ Kewley et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
The von Hippel-Lindau tumor suppressor gene and kidney cancer
WG Kaelin
CLINICAL CANCER RESEARCH (2004)
Medical progress - Management of cutaneous melanoma
H Tsao et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML
CHM Jamieson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Fatty acid synthase: A metabolic oncogene in prostate cancer?
A Baron et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4
ZX Liang et al.
CANCER RESEARCH (2004)
Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer
DP Petrylak et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer
IF Tannock et al.
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
BJ Moeller et al.
CANCER CELL (2004)
Hypoxia-inducible factors 1α and 2α are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
A Giatromanolaki et al.
MELANOMA RESEARCH (2003)
Regulation of hypoxia-inducible factor-1α, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer
O Stoeltzing et al.
AMERICAN JOURNAL OF PATHOLOGY (2003)
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
J Lessard et al.
NATURE (2003)
Prospective identification of tumorigenic breast cancer cells
M Al-Hajj et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Levels of hypoxia-inducible factor-1α independently predict prognosis in patients with lymph node negative breast carcinoma
R Bos et al.
CANCER (2003)
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
R Fukuda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Enhanced overexpression of an HIF-1/hypoxia-related protein in cancer cells
H Cangul et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2002)
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
CC Hudson et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Cellular adaptation to hypoxia:: O2-sensing protein hydroxylases, hypoxia-inducible transcription factors, and O2-regulated gene expression
RH Wenger
FASEB JOURNAL (2002)
Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro
SM Graham et al.
BLOOD (2002)
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis:: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
E Laughner et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the philadelphia chromosome.
BJ Druker et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Involvement of chemokine receptors in breast cancer metastasis
A Müller et al.
NATURE (2001)
AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation
T Miyamoto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1 alpha
P Carrero et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)