期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 18, 期 1, 页码 15-26出版社
WILEY
DOI: 10.1111/jcmm.12159
关键词
chronic lung diseases; COPD; gene; biomarkers; polymorphism; therapy
资金
- Shanghai Leading Academic Discipline Project [B115]
- Shanghai Young Clinicians Nurturing Plan
- Zhongshan Distinguished Professor Grant
- National Nature Science Foundation of China [91230204, 81270099, 81320108001]
- Shanghai Committee of Science and Technology [12JC1402200, 12431900207, 11410708600]
The genetic component was suggested to contribute to the development of chronic obstructive pulmonary disease (COPD), a major and growing public health burden. The present review aims to characterize the evidence that gene polymorphisms contribute to the aetiology of COPD and related traits, and explore the potential relationship between certain gene polymorphisms and COPD susceptibility, severity, lung function, phenotypes, or drug effects, even though limited results from related studies lacked consistency. Most of these studies were association studies, rather than confirmatory studies. More large-sized and strictly controlled studies are needed to prove the relationship between gene polymorphisms and the reviewed traits. More importantly, prospective confirmatory studies beyond initial association studies will be necessary to evaluate true relationships between gene polymorphisms and COPD and help individualized treatment for patients with COPD.
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