期刊
NEUROIMAGE
卷 113, 期 -, 页码 37-43出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.03.018
关键词
Ultrahigh fields; Functional MRI; Spatiotemporal encoding; BOLD activation; T1 contrast; Forepaw stimulation
资金
- UNIRS Laboratory (NeuroSpin/I2BM/DSV/CEA)
- EU (through ERC Advanced Grant) [246754]
- Kimmel Institute for Magnetic Resonance
- Perlman Family Foundation
- EC Marie Curie Action ITN METAFLUX [264780]
- grants GIS-IBISA (France)
- Israel Science Foundation [795/13]
This manuscript examines the origins and nature of the function-derived activation detected by magnetic resonance imaging at ultrahigh fields using different encoding methods. A series of preclinical high field (7 T) and ultra-high field (17.2 T) fMRI experiments were performed using gradient echo EPI, spin echo EPI and spatio-temporally encoded (SPEN) strategies. The dependencies of the fMRI signal change on the strength of the magnetic field and on different acquisition and sequence parameters were investigated. Artifact-free rat brain images with good resolution in all areas, as well as significant localized activation maps upon forepaw stimulation, were obtained in a single scan using fully refocused SPEN sequences devoid of T2* effects. Our results showed that, besides the normal T2-weighted BOLD contribution that arises in spin-echo sequences, fMRI SPEN signals contain a strong component caused by apparent T1-related effects, demonstrating the potential of such technique for exploring functional activation in rodents and on humans at ultrahigh fields. (C) 2015 Elsevier Inc. All rights reserved.
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