期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 13, 期 9A, 页码 2949-2951出版社
WILEY
DOI: 10.1111/j.1582-4934.2009.00869.x
关键词
(sub)epicardium; epithelial-mesenchymal transition (EMT); isolated smooth muscle cells; interstitial Cajal-like cells (ICLCs); mesothelial cells; mesenchymal cells; cardiac regeneration
The human sub-epicardial area contains an unexplored cellular population under a layer of mesothelial cells. Transmission electron microscopy revealed the existence of interstitial Cajal-like cells (ICLCs), isolated smooth muscle cells (iSMC) and mesenchymal cells besides other well-known cells. The presence of iSMC in the sub-epicardial space is quite unique and could explain why epicardial-derived cells isolated from human epicardium generate smooth muscle cells in culture. Mesenchymal cells, guided by ICLCs, were found migrating from sub-epicardial area in the mesothelial layer. These findings suggest that epithelial-mesenchymal transition is not a common process involved in cardiac regeneration in vivo.
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