期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 12, 期 5B, 页码 1795-1810出版社
WILEY
DOI: 10.1111/j.1582-4934.2008.00457.x
关键词
mesenchymal stem cells; ICLCs; regenerative medicine; heart muscle; repair mechanisms; ex vivo cell manipulation
资金
- German Helmholtz Association
- Mecklenburg-Vorpommern
- German Research Foundation
- SFB/Transregio 37
- BMBF START-MSC
Accumulating clinical and experimental evidence indicates that mesenchymal stem cells (MSCs) are promising cell types in the treatment of cardiac dysfunction. They may trigger production of reparative growth factors, replace damaged cells and create an environment that favours endogenous cardiac repair. However, identifying mechanisms which regulate the role of MSCs in cardiac repair is still at work. To achieve the maximal clinical benefits, ex vivo manipulation can further enhance MSC therapeutic potential. This review focuses on the mechanism of MSCs in cardiac repair, with emphasis on ex vivo manipulation.
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