期刊
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
卷 12, 期 5A, 页码 1502-1516出版社
WILEY
DOI: 10.1111/j.1582-4934.2008.00292.x
关键词
apoptosis; inhibitors; inflammation; transplant
资金
- Research Council for Science Engineering and Technology (IRSCET)
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic strategy. Problems facing the development of effective and safe caspase therapeutics will also be addressed.
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