期刊
JOURNAL OF CELL SCIENCE
卷 128, 期 1, 页码 33-39出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.159145
关键词
Axin; Conductin; Dvl; Negative feedback; Wnt
类别
资金
- Friedrich-Alexander Universitat Erlangen-Nurnberg
- Deutsche Forschungsgemeinschaft [KFO257]
Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/beta-catenin signalling that promote degradation of beta-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their functional interaction with the upstream Wnt pathway component Dvl. Conductin shows reduced binding to Dvl2 compared to axin, and degradation of beta-catenin by conductin is only poorly blocked by Dvl2. We propose that insensitivity to Dvl is an important feature of the role of conductin as a negative-feedback regulator of Wnt signalling.
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