期刊
JOURNAL OF CELL SCIENCE
卷 127, 期 21, 页码 4692-4701出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.154500
关键词
Breast cancer; mRNA; MLN51; P-bodies; Stress granules
类别
资金
- French National Agency [ANR-08JCJC-0027-01, ANR-09-MIE]
- Institut Universitaire de France
- Ligue Nationale Contre le Cancer
- Fondation pour la Recherche Medicale (FRM)
- Ligue Nationale Contre Le Cancer (CCIR-GE)
Metastatic lymph node 51 (MLN51, also known as CASC3) is a core component of the exon junction complex (EJC), which is loaded onto spliced mRNAs and plays an essential role in determining their fate. Unlike the three other EJC core components [eIF4AIII, Magoh and Y14 (also known as RBM8A)], MLN51 is mainly located in the cytoplasm, where it plays a key role in the assembly of stress granules. In this study, we further investigated the cytoplasmic role of MLN51. We show that MLN51 is a new component of processing bodies (P-bodies). When overexpressed, MLN51 localizes in novel small cytoplasmic foci. These contain RNA, show directed movements and are distinct from stress granules and P-bodies. The appearance of these foci correlates with the process of P-body disassembly. A similar reduction in P-body count is also observed in human HER2-positive (HER2(+)) breast cancer cells overexpressing MLN51. This suggests that P-body disassembly and subsequent mRNA deregulation might correlate with cancer progression.
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