期刊
NEUROIMAGE
卷 109, 期 -, 页码 469-479出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.01.005
关键词
Very preterm; MRI; Cortical surface; Volume; Folding; Relative surface area; Structural abnormality
资金
- NIH [R01 HD05709801, R01 MH60974, P30 HD062171]
- Doris Duke Foundation Distinguished Clinical Scientist Award
- National Medical and Health Research Council of Australia Project Grants [237117, 491209]
- Senior Research Fellowship [628371]
- Victorian Government's Operational Infrastructure Support Program
We analyzed long-lasting alterations in brain morphometry associated with preterm birth using volumetric and surface-based analyses applied to children at age 7 years. Comparison of 24 children born very preterm(VPT) to 24 healthy term-born children revealed reductions in total cortical gray matter volume, white matter volume, cortical surface area and gyrification index. Regional cortical shape abnormalities in VPT children included the following: shallower anterior superior temporal sulci, smaller relative surface area in the inferior sensorimotor cortex and posterior superior temporal cortex, larger relative surface area and a cingulate sulcus that was shorter or more interrupted in medial frontoparietal cortex. These findings indicate a complex pattern of regional vulnerabilities in brain development that may contribute to the diverse and long-lasting neurobehavioral consequences that can occur after very premature birth. (C) 2015 Elsevier Inc. All rights reserved.
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