期刊
JOURNAL OF CELL SCIENCE
卷 126, 期 5, 页码 1071-1080出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.115626
关键词
Microtubule; Macroautophagy; Phagocytosis; Phagophore; Cell signaling; Lysosome; Acetylation; Molecular motor
类别
资金
- Universite Paris-Sud
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Universite Paris Descartes
Both at a basal level and after induction (especially in response to nutrient starvation), the function of autophagy is to allow cells to degrade and recycle damaged organelles, proteins and other biological constituents. Here, we focus on the role microtubules have in autophagosome formation, autophagosome transport across the cytoplasm and in the formation of autolysosomes. Recent insights into the exact relationship between autophagy and microtubules now point to the importance of microtubule dynamics, tubulin post-translational modifications and microtubule motors in the autophagy process. Such factors regulate signaling pathways that converge to stimulate autophagosome formation. They also orchestrate the movements of pre-autophagosomal structures and autophagosomes or more globally organize and localize immature and mature autophagosomes and lysosomes. Most of the factors that now appear to link microtubules to autophagosome formation or to autophagosome dynamics and fate were identified initially without the notion that sequestration, recruitment and/or interaction with microtubules contribute to their function. Spatial and temporal coordination of many stages in the life of autophagosomes thus underlines the integrative role of microtubules and progressively reveals hidden parts of the autophagy machinery.
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