期刊
JOURNAL OF CELL SCIENCE
卷 126, 期 9, 页码 2114-2123出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jcs.125690
关键词
P-bodies; Kinesin motor protein; PSD-95; Actin cytoskeleton; Synaptic plasticity
类别
资金
- Korea Research Foundation (KRF) grant
- Korea government (MEST) [2009-0074616, 2012-0005751]
- National Research Foundation of Korea [2009-0074616] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
In neurons, transport of a subset of mRNAs to subcellular regions and their translation has a role in synaptic plasticity. Recent studies have suggested a control mechanism of this local translation through mRNA compartmentalization or degradation. Here we report that processing bodies (P-bodies), which are involved in mRNA degradation or storage, are transported to dendrites by conventional kinesin (KIF5A) as a motor protein. Neuronal activation induced by depolarization increased the colocalization of P-bodies with PSD-95 in dendrites. This neuronal activity increased the release of Nd1 and Arp2 mRNA from the P-bodies and, consequently, reversed the decrease of F-actin (induced by overexpression of Dcp1a) in the dendrites. Our data suggest that the activity-induced redistribution of P-bodies and mRNA release from P-bodies might have a role in synaptic structural plasticity by altering levels of mRNAs that are involved in the dynamics of the actin cytoskeleton in dendrites.
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